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Professor Bishop anticipates that the study will generate new knowledge regarding oral bisphosphonate therapy in children with OI - no previous dose-ranging studies have been reported - and that this study may help define how children with this disabling condition are treated in the future.

The broader health economic benefits of this kind of work will reflect both the immediate effect on families - fewer trips to A&E for fractures - and the longer term health and work prospects of the treated individuals themselves.